Structural Heart

Why Mechanical AVR Valves Still Matter

A presentation at this year’s Society of Thoracic Surgeons (STS) conference suggests mechanical valves might lead to better survival compared to bioprosthetic valves in patients aged 60 or younger undergoing SAVR even though it seems like they’re going out of style.

  • Mechanical SAVR valves have been around in one form or another since the 1960s, but have fallen out of favor in recent years.
  • Previous analyses suggested mechanical valves have advantages over tissue valves in middle-aged patients, but lifelong anticoagulation requirements makes them a hard sell. 

Researchers examined STS registry data on ~109k patients ages 40 to 75 years who received isolated bioprosthetic (94k) or mechanical (15k) AVR over 11 years and found that mechanical valve use decreased by about half (from 20% in 2008 to below 10% in 2019).

Despite the declining use of mechanical AVR, its benefits were clear over the study’s median 5.4 year follow-up, with patients aged 40-59 seeing the most significant mortality benefits.

  • Patients aged 40-49 had a 31% lower all-cause mortality risk when receiving mechanical AVR compared to bioprosthetic.
  • For patients aged 50-59, the benefit was less dramatic, but still significant coming in at a 13% lower all-cause mortality risk.

While these mortality risks might seem convincing, there are several caveats to keep in mind, including the significant differences in patient characteristics between mechanical and bioprosthetic recipients.

  • Patients receiving bioprosthetic valves tended to be older (65.2 vs 55.7 years).
  • They also often had lower BMI (31.0 vs 32.2 kg/m2).
  • Bioprosthetic patients also had higher rates of hypertension (78.7% vs 71.8%) or prior PCI (6.7 vs 3.7%).
  • However, bioprosthetic recipients had severe aortic insufficiency less often (15.3% vs 23.6%).

The study’s design also wasn’t powered to make any certain conclusions due to its reliance on registry data, meaning a randomized head-to-head trial would be needed to confirm these outcomes.

The Takeaway

When it comes to AVR, it’s pretty clear that it’s not a “one-valve fits all” type of situation, especially in the case of mechanical valves. While the data is still less-than-certain, this presentation suggests that there could be benefits to keeping mechanical AVR on the table, at least for healthier patients under 60.

Get twice-weekly insights on the biggest stories shaping cardiology.

You might also like

Surgeries & Interventions June 23, 2025

Edwards’ Evoque Might Have More Adverse Events Than Previously Known June 23, 2025

Over a year after becoming the first FDA-approved transcatheter tricuspid valve replacement system, a new JACC study suggests Edwards Lifesciences’ Evoque TTVR system might have some risks that regulators hadn’t previously considered. Searching for more answers about Evoque’s real world risks, researchers pulled data from the FDA’s Manufacturer and User Facility Device Experience (MAUDE) database […]

Cardiology Business June 19, 2025

Lilly Buys Verve, Bringing Gene Editing Mainstream June 19, 2025

Gene editing for heart disease just got a major boost as Eli Lilly acquired Verve Therapeutics and its one-dose cholesterol drugs for up to $1.3B, marking a new path for Verve’s therapies to go mainstream. Part of the acquisition likely stems from Verve’s recent impressive trial results for its PCSK9-blocking treatment, VERVE-102, which lowered LDL-C […]

Cardiac Imaging June 19, 2025

New AI-driven Tool Aids in Mitral Valve Assessment June 19, 2025

By: Jimmy Su, Ph.D. Principal Scientist, Cardiovascular Ultrasound, Philips A new tool, Automated 3D Color Flow Quantification (3D Auto CFQ), removes the reliance on assumptions when quantifying mitral regurgitation and replaces it with a reliable and robust, AI-driven method that delivers precise measurement of mitral valve regurgitant volume (RVol) regardless of orifice shape and size. Eliminating assumptions: Quantification […]

You might also like..

Select All

You're signed up!

It's great to have you as a reader. Check your inbox for a welcome email.

-- The Cardiac Wire Team

You're all set!