Despite society guidelines and extensive clinical evidence demonstrating that traditional wire-based coronary physiology improves outcomes and reduces costs compared to angiography alone1-2, physiology continues to be disappointingly underutilized globally due to the inconvenience and time it adds to the procedure.
The novel CathWorks FFRangio System combines artificial intelligence and advanced computational science to obtain physiologic information from routine diagnostic angiograms, eliminating the hassle associated with invasive pressure wires and drug stimulation.
CathWorks FFRangio technology goes beyond physiology and provides physicians with a comprehensive suite of intraprocedural tools to facilitate more informed treatment decisions for their patients with coronary artery disease (CAD) in everyday practice.
The system provides a comprehensive suite of intraprocedural tools to optimize clinical decision making.
- Real-time FFRangio values across the coronary tree enable streamlined assessment in multi-vessel disease.
- Simulated pullback curve differentiates functional patterns of CAD to target treatment.
- Lesion Impact tool enables excluding a lesion in tandem lesion cases to assess residual ischemia.*†
- Integrated sizing tool, co-registered on the angiograms, provides non-invasive lesion measurements to support PCI planning.
FFRangio also demonstrates the highest diagnostic accuracy and promising outcomes.
- Highest diagnostic accuracy versus wire-based fractional flow reserve (FFR) among non-hyperemic indices and angio-based technologies.3-5
- Excellent outcomes in randomized and real-world studies, consistent with results from large FFR datasets.6-8
The FFRangio System integrates seamlessly into the cath lab and streamlines procedural workflow.
- Artificial intelligence aids in quick angiogram analysis and minimizes manual edits.
- Allows for functional assessment to be performed on one side of the heart while acquiring images of the other side.
- Enables seamless integration with the boom and PACS.
The Takeaway
The CathWorks FFRangio System addresses the limitations of traditional invasive physiology and helps elevate clinical decision making with its comprehensive suite of tools.
Hear how global physician experts are transforming their cath labs with the FFRangio System. https://youtu.be/yic02qisEtI
Learn more at www.cath.works.
References:
* Lesion Impact feature is only available in selected geographies.
† Lesion Impact feature is not available for Diagonal and Ramus cases.
- Tonino P et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. NEJM. 2009;360-213-224.
- Fearon W et al. Economic evaluation of fractional flow reserve–guided percutaneous coronary intervention in patients with multivessel disease. Circulation. 2010;122:2545-2550.
- Witberg G et al. Diagnostic performance of angiogram-derived fractional flow reserve: a pooled analysis of 5 prospective cohort studies. J Am Coll Cardiol Intv. 2020;13(4):488-97.
- Johnson N et al. Angio-derived fractional flow reserve versus invasive nonhyperemic pressure ratios. JACC VOL. 73, NO. 24, 2019;3230-3233.
- Skalidis I et al. Head-to-head comparison of two angiography-derived fractional flow reserve techniques in patients with high-risk acute coronary syndrome: A multicenter prospective study. Int J Cardiol 2023 Dec 21:131663.
- Tanigaki T et al. Prospective randomized clinical outcomes of angiography-based fractional flow reserve guidance versus wire-based fractional flow reserve, PROVISION Trial, as presented at EuroPCR 2025. UMIN clinical registry ID: UMIN000049230.
- Witberg G et al. One-year clinical outcomes of FFR angio-guided treatment of coronary artery disease, as presented at EuroPCR 2023.
- Sara JDS et al. Clinical implementation of FFRangio for revascularization guidance: multicenter U.S. experience, as presented at TCT 2025.
