Preventive Cardiology

America’s CKM Syndrome Problem

A new JAMA study revealed that a shocking 90% of US adults are at risk of developing cardiovascular-kidney-metabolic (CKM) syndrome, underscoring the need for preventative action before we face a wave of CKM-related heart disease.

  • Officially published by the AHA six months ago, CKM syndrome defines the connections and risks associated with obesity, type 2 diabetes, chronic kidney disease, and cardiovascular disease.

The researchers analyzed 2011-2020 NHANES survey results and laboratory measurements from 10,762 nationally representative US adults (47.3yr avg. age, 51.8% women, 64.4% White) to assess their CKM stages, finding the following breakdown:

  • Stage 0 (no risk factors) – 10.6%
  • Stage 1 (overweight, prediabetes) – 25.9%
  • Stage 2 (metabolic risk factors like hypertension, diabetes, CKD) – 49%
  • Stage 3 (kidney disease or high cardiovascular risks) – 5.4%
  • Stage 4 (heart disease, with or without kidney disease) – 9.2%

In other words, half of US adults have moderate CKM syndrome risks (Stage 2), and nearly a sixth of adult Americans already have advanced CKM syndrome (Stages 3 & 4). Yikes.

These rates stayed relatively stable throughout the study period, while certain groups were far more likely to have advanced stage CKM syndrome including those older than 65 (55.3% vs. 10.7% in 45-64yrs), men (16.9% vs. 12.4% in Women), and Black people (18.9% vs. 13.8% in Whites).

The Takeaway

Many Cardiac Wire readers shouldn’t be surprised by these numbers, noting the mounting evidence that diabetes, obesity, and hypertension rates are skyrocketing. However, the fact that 90% of US adults have high CKM syndrome risks is still shocking, and underscores the urgent need to improve CKM prevention and care.

Get twice-weekly insights on the biggest stories shaping cardiology.

You might also like

Cardiology Pharmaceuticals August 7, 2025

SURPASS-CVOT Shows Mounjaro Surpasses Trulicity in CV Outcomes August 7, 2025

The largest and longest tirzepatide study to date just confirmed that Eli Lilly’s Mounjaro has surpassed its older GLP-1, Trulicity, in practically every way, with significant gains when it comes to cardiovascular benefits. The SURPASS-CVOT study represents the most comprehensive incretin analysis to date, comparing MACE rates in 13k T2D patients with ASCVD on either […]

Cardiovascular Disease August 4, 2025

The Impact of Physical Activity Before and After CV Events August 4, 2025

A long-term analysis of the CARDIA study revealed that moderate-to-vigorous physical activity steadily declines from young adulthood through midlife, but patients destined to develop cardiovascular disease experience rapid activity decreases more than a decade before their first event. Collecting data over 37 years, researchers tracked ~3k participants from young adulthood to middle age and paired […]

Cardiology Pharmaceuticals July 31, 2025

AstraZeneca’s Anselamimab Comes Up Short in Phase 3 Trial July 31, 2025

In a setback to one of its rarer disease pipelines, AstraZeneca’s amyloidosis antibody, anselamimab, failed to significantly reduce all-cause mortality and CV hospitalizations in the CARES Phase 3 trial’s overall patient population.  The CARES clinical program was the largest prospective cardiac AL amyloidosis investigation to date, enrolling 406 patients to test whether anselamimab could reduce […]

You might also like..

Select All

You're signed up!

It's great to have you as a reader. Check your inbox for a welcome email.

-- The Cardiac Wire Team

You're all set!