Cardiovascular Disease Solutions

Six-Year Study Sheds Light on Intermittent Fasting

We hear a lot about the benefits of intermittent fasting, but a six-year study in JAHA revealed that timing from the first meal to the last meal might not affect weight loss. Instead, the number and size of meals may be the more important factor.

Although intermittent fasting has become a popular weight-loss strategy, rigorously designed studies have yet to determine whether restricting the eating window can effectively control body weight in the long run.

For the study, the research team created a mobile app for 550 participants to catalog daily habits in real-time. Participants were regularly prompted to use the app during the first month and again during “power weeks”—one week per month for the six-month intervention period. 

After six years, the authors found:

  • Meal timing was not associated with weight change.
    • This includes the interval from first to last meal, from waking to eating a first meal, from eating the last meal to going to sleep, and total sleep duration.
  • Instead, the daily number of large (over 1k calories) and medium (500-1k calories) meals were each tied to increased weight.
  • Fewer small meals (under 500 calories) was tied to decreased weight.

The Takeaway

There has been much debate about the weight benefits of intermittent fasting. Does the timing of when one consumes their meals really matter, or is it merely the fact that eating within a tighter window encourages reduced caloric intake? This study appears to provide evidence that it is more about eating smaller and fewer meals that benefits people, rather than when exactly those meals are eaten. 

Get twice-weekly insights on the biggest stories shaping cardiology.

You might also like

Electrophysiology August 21, 2025

Conduction-System Pacing Succeeds at Treating AV Block August 21, 2025

Conduction-system pacing could be poised to reshape standard care for atrioventricular (AV) block patients after the randomized CSPACE trial demonstrated its significant benefits over traditional right ventricular septal pacing. Taking a closer look at CSP’s potential, the CSPACE trial enrolled 202 patients with AV block at two Australian hospitals, randomizing them to conduction-system pacing or […]

Cardiology Pharmaceuticals August 18, 2025

Rivaroxaban Monotherapy Could Be Better for CAD + AFib August 18, 2025

New analysis from the AFIRE trial suggests rivaroxaban monotherapy might be emerging as a preferred antithrombotic strategy for patients with AFib and stable coronary artery disease, especially in older age groups. The Post Hoc AFIRE Analysis examined 2,215 Japanese patients with AFib and stable CAD, stratifying them into four age groups (<70, 70-74, 75-79, and […]

Surgeries & Interventions August 14, 2025

TEER Could Save Lives in AFMR Patients August 14, 2025

Shedding light on a new treatment for an understudied condition, data published in EHJ suggests that transcatheter edge-to-edge repair (TEER) delivers significant survival advantages in patients with atrial functional mitral regurgitation (FMR). The new OCEAN-Mitral/REVEAL-AFMR Analysis compared 441 TEER-treated patients against 640 medically managed controls with moderate or severe atrial FMR, stating a solid case […]

You might also like..

Select All

You're signed up!

It's great to have you as a reader. Check your inbox for a welcome email.

-- The Cardiac Wire Team

You're all set!