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Heart Failure October 7, 2024
Finerenone’s Early Heart Failure Impact October 7, 2024
The FINEARTS-HF trial already showed that Bayer’s nsMRA finerenone (Kerendia) has the potential to slash mortality and event rates in HFpEF and HFmrEF patients, and new analysis suggests that its impact could be even greater if used earlier. The original FINEARTS-HF trial presented at ESC 2024 saw finerenone drive a 16% reduction in cardiovascular death […]
Heart Failure October 3, 2024
EMBARK-HFpEF Trial Flexes Mavacamten’s HF Potential October 3, 2024
A new HFpEF treatment might be on the horizon, after results from the EMBARK-HFpEF trial showed that BMS’ hypertrophic cardiomyopathy treatment, mavacamten (Camzyos), safely improved key HFpEF symptoms and biomarkers. To test mavacamten’s HFpEF potential, the open-label Phase 2a EMBARK-HFpEF trial treated 30 HFpEF patients with mavacamten (avg age 76, NYHA Class II & III, […]
Preventive Cardiology September 30, 2024
Cancer’s CVD Risks and SGLT2is’ Preventative Potential September 30, 2024
Better treatments have led to improved cancer survival rates, but new research reveals increased cardiovascular complications in survivors. However, another new study offers hope, suggesting that heart medications like SGLT2 inhibitors may help prevent cancer-related heart disease. A new Cancer Journal study showed that older cancer survivors have far higher rates of cardiovascular events than […]
Heart Failure September 26, 2024
Windtree’s Istaroxime Scores in Cardiogenic Shock Trial September 26, 2024
Windtree Therapeutics’ istaroxime appears to have scored in its latest Phase 2b trial, showing that the steroidal drug significantly improves systolic blood pressure in cardiogenic shock patients. The Phase 2b SEISMiC extension trial evaluated istaroxime infusions for up to 60 hours in patients with early-stage cardiogenic shock, measuring its impact during the first 96 hours […]